One approach to tackle this problem is through chemical modification
of the FFA. By converting FFA into a different functional
group, e.g., fatty acid methyl esters (FAME), the separation factor
between the esters and squalene in scCO2 is improved and better
separation efficiency can be obtained [5]. Alternative strategies
have been recently reported using scCO2 technology in combination
with membrane separation, which moderately improve separation
efficiency