These results suggest that ACA exhibited M1 polarization and
differentiation in macrophages. Lin et al. (2010) isolated a new
immunomodulatory protein GMI from Ganoderma microsporum and
investigated its activity in suppressing tumor invasion and metastasis. It
was found that GMI, in a dose-dependent manner, inhibits epidermal
growth factor mediated migration and invasion in A549 lung cancer
cells by several pathways such as inhibiting EGF-induced phosphorylation,
EGF-induced activation of Cdc42 GTPase, activation of EGFR
and Ala pathway kinases.