The presence of arsenic (As) in agricultural food products is a matter of concern because it can cause adverse
health effects at low concentrations. Agricultural-product intake constitutes a principal source for As exposure
in humans. In this study, the contribution of the chemical-soil parameters in As accumulation and translocation
in themaize crop from amining area of San Luis Potosiwas evaluated. The total arsenic concentration and arsenic
speciationwere determined by HG-AFS and IC–HG-AFS, respectively. The data analysiswas conducted by cluster
analysis (CA) and principal component analysis (PCA). The soil pH presented a negative correlation with the
accumulated As in each maize plant part, and parameters such as iron (Fe) and manganese (Mn) presented a
higher correlation with the As translocation in maize. Thus, the metabolic stress in maize may induce organic
acid exudation leading a higher As bioavailability. A high As inorganic/organic ratio in ediblemaize plant tissues
suggests a substantial risk of poisoning by this metalloid. Careful attention to the chemical changes in the
rhizosphere of the agricultural zones that can affect As transfer through the food chain could reduce the
As-intoxication risk of maize consumers.