Cats may be important in the ecology of HPAI H5N1 for multiple reasons. During H5N1 virus outbreaks among poultry, domestic cats have often been observed to feed upon the bird carcasses. Second, cats often freely move between multiple species including humans and poultry with the potential to further spread the pathogen to man or unaffected flocks. Third, as some cats readily tolerate HPAI H5N1, they have potential to serve as a reservoir for the AIVs to adapt to mammals, thereby increasing the risk of a human influenza pandemic [9]. Direct contact with sick or diseased poultry has been implicated as a major risk factor for feline infection with H5N1 AIV [5], [6] and [10].