The test site for wrinkle reduction and skin smoothening was the “crow’s feet” at the outer corner of the eye. SkinSys software (Sometech Inc, Seoul, South Korea) and a Coccam digital camera (Beauty Korea World Co Ltd, Seoul, South Korea) were used. SkinSys is professional skin analysis and treatment software that enables the user to perform a wellorganized scientific evaluation of cosmetic products. The skin analysis and measuring functions include: 1) 3D analysis of skin curvature (wrinkle reduction); and 2) analysis of keratin content by using a precise edge-detection algorithm.