3.3. Optimized control of the concentrations of glucose and total nitrogen in fed batch fermentation
The optimal control of the concentration of glucose and total nitrogen from the 11th h to 15th h of cultivation versus the maximum cell dry weight was conducted by CCD. The design matrix and the corresponding experimental data are given in Table 1. The experimental results of the CCD were fit to a second-order polynomial in [Equation 6]:
equation[Equation 6]
Y=74.5+7.42X1+5.58X2‐X1X2‐9.31X12‐9.06X22