The present study showed that chronic stimulation of skeletal muscle increased palmitate oxidation and esterification. A novel and significant finding is the demonstration that this was associated with an increase in FA transport, measured in sarcolemmal vesicles, and with an increase in the FA transporter FAT/CD36. This strongly suggests that increasing the muscle capacity for oxidizing FA requires a concurrent increase in membrane FA transport, and that FA transport may be the rate-limiting factor for FA metabolism.
expression