Baseline plasma concentrations of 8-epi-PGF2 were significantly higher (P = 0.03) among the men (249.6 ± 25.4 pg/mL) than among the women (177.7 ± 6.2 pg/mL; Table 2). Interestingly,we observed a trend toward a decrease in plasma concentrations of 8-epi-PGF2 among the men on day 7 of the intervention, which became significant on day 14 (P = 0.04). No significant changes were observed by time among the women.