mechanism of Brucella is the BvrR/BvrS two-component regulatory system, which is required for modulation of the host cell cytoskeleton upon Brucella invasion, and for regulation of the expression of outer membrane proteins, some of which are required for full virulence (39). Cyclic β-1,2-glucans, which are also part of the outer membrane,
are also required for intracellular survival of Brucella (13).