Broken red rice (Oryza sativa var. Sukhothai 1) is a milling byproduct that is rich in nutrients such as vitamins and antioxidants. Transformation of the rice into an extract drink would increase its economic value as well as encourage consumptions of functional foods. Production of red rice drink extracted from its pericarp or bran was thus optimized for the maximum quality. A combination of ultraviolet (UV) radiation and ultrasonication was utilized to reduce starch leaching and increase antioxidation levels. UV radiation was first applied on dry or moist grain for 0, 30, or 60 min. The grain was then soaked in a commercial drinking water using ultrasonication at 28 kHZ, 50°C for 60 min or at 100 kHZ, 60°C for 120 min. Numbers of total bacteria as well as yeast and mold were enumerated after both processes while an antioxidant activity was evaluated in the final products. After radiation under UV for at least 30 min, the lower count of total bacteria was significantly marked in moist grain (p0.05). Using the dry grain, an antioxidant activity was significantly lowered over a longer period of UV radiation as well as a higher frequency of ultrasonication (p