The purpose of this research is the development of the skills of observation by inquiry method (5E) group learning science , title classification of plants and reproduction of animals and propagation.For prathomsuksa 5 with a population is prathomsuksa 5 number 10 people during the academic year 2557 which comes from the purposive sampling. The instruments used in the study include is learn a lesson plan by inquiry method (5E) , 2 lesson plans for title classification of plants and reproduction of animals and propagation and use the pre-test and post-test.