HPC Met granulates absorbed 0.29% moisture at 50% RH. On the other hand, VA64 and PVP Met granulates absorbed 0.49% and 0.80% moisture, respectively, at 50% RH. VA64 and PVP Met granulates absorbed 1.7–2.8 times more moisture than HPC Met granulates. HPC Met granulates had the lowest moisture absorbency; therefore, HPC may have a limited capacity of water uptake compared to VA64 and PVP. The binder may have an impact on the moisture absorbency of Met granulates. Addition of 1.0% or 1.5% of water was too high for HPC Met granulates, and a tendency to block was observed during the tableting process.