There was no significant difference in estimates of omega-3 fatty acid efficacy based on
whether omega-3 fatty acids were given as monotherapy or augmentation (test for subgroup
differences χ2 = 1.8, df = 1 (p= 0.17); I2 = 46%). The estimate of effect in trials which
omega-3 FAs were given as monotherapy was 0.20 (95%CI: 0,0.39), whereas the effect
estimate was -0.02 (95%CI: -0.26,0.22) in trials in which concomitant pharmacotherapy was
allowed.