Similar approaches have described how to removecoverslips from Araldite-mounted preparations using an iceblock on the surface of the coverslip and liquid nitrogen.3Apparently the basic principle consists of the differences infreezingbetweentheglassslideandthemountingmedia.Archival stained smears and cytospin preparations are aprecious source of DNA for molecular analysis and in somecases might be the only resource for detecting molecularabnormalities such as mutations in epidermal growth factorreceptor (EGFR), BRAF, and KRAS genes to direct targetedtherapies.4,5We anticipate the broad use of archival slides instudies involving cases with exhausted histological mate-rial or those with only cytological specimens as a sourcefor DNA. The “freezer method” for coverslip removal canfacilitate the preparation of these samples.