She assists the new Vault Hunters in stopping Handsome Jack, similarly to the first game. It is also revealed that Angel betrayed the first Vault Hunters at some point, nearly resulting in their deaths during an attack on New Haven. She betrays the new Vault Hunters as well, deactivating Sanctuary's shields, and rendering the city vulnerable to Hyperion mortar strikes, which almost demolishes Sanctuary. After said events, however, she expresses regret for doing so, and turns on Handsome Jack, and continues to assist the Vault Hunters.