Suzuki et al.[40] studied the mechanism of antiplaque
action of diamine silver fluoride (Ag(NH3)2F). This agent
showed excellent antibacterial action against cariogenic
strains of S. mutans (minimal inhibitory concentration,
0.12 μmole/ml), and completely inhibited the dextraninduced
agglutination of S. mutans at 0.59 μmole/ml and
sucrase activities of S. mutans at 0.2 μmole/ml. These
effects were found to be the result of the action of silver
ion. These results indicate that silver ion may inhibit the
colonization of S. mutans on enamel surface and offer a
possible explanation for the antiplaque action of the agent