It was interesting to note that our tested population demographics
revealed that a large percentage of our schizophrenia subjects, twice
as many as the control group, had a family history of mental disorders
(either mother, father or both parents), or experienced some sort of
trauma or adversity during their childhood (Table 1). χ2 analysis revealed
that the WNK1 rs1468326 SNP had a significant allelic and genotypic
association with schizophrenia in those subjects who had a
mother with a history of mental disorders (5.82 ≥ χ2 ≥ 6.38,
0.01 ≥ p ≥ 0.04; Table 6). In subjects who experienced some sort of
adversity during childhood, there was a significant genotypic but not
allelic association with schizophrenia for the Myt1l SNP rs3748988
(χ2 = 7.72, p = 0.02; Table 6). None of the other tested SNPs in any
of the genes displayed any significance when analyzed according to a
family history of mental disorders or traumatic childhood (p N 0.05).
Again, following Bonferroni correction for multiple testing, significance
for the allelic and genotypic WNK1 associations in schizophrenia subjects
with a maternal history of mental disorders, and the genotypic
Myt1l association with schizophrenia in subjects who experienced
childhood trauma was lost.