8. Reduce Derivatives
Unnecessary derivatization (use
of blocking groups, protection/
deprotection, temporary modification
of physical/chemical processes) should
be minimized or avoided if possible,
because such steps require additional
reagents and can generate waste.
9. Catalysis
Catalytic reagents (as selective as
possible) are superior to stoichiometric
reagents.
10. Design for Degradation
Chemical products should be designed
so that at the end of their function they
break down into innocuous degradation
products and do not persist in the
environment.