Management of CRC relies primarily on resection of the bowel with the adjacent draining lymph nodes. The need for neoadjuvant or adjuvant chemotherapy, with or without concurrent irradiation, depends on tumor location (colon vs rectum) and stage of disease. In surgery for both colon and rectal cancers, if the tumor is attached to other organs, an en bloc resection of the primary tumor and adjacent organ(s) is indicated. If the adhesions are violated, there is an increase in local recurrence and a decrease in survival; thus, the potential cure for that patient will be compromised. Occasionally, neoadjuvant chemoradiation therapy will be indicated in colon tumors before surgical resection. In rectal cancer, preoperative (preferred) or postoperative chemoradiation is indicated for stages II and III disease. - See more at: http://www.cancernetwork.com/cancer-management/colon-rectal-and-anal-cancers/page/0/3#sthash.St5tTOZ9.dpuf