ilapia is one of the most productive and internationally traded food fish in the world. The production of farmed tilapia is among the fastest expanding food sectors in the world. Nile tilapia (Oreochromis niloticus) is the most cultured freshwater species among the farmed tilapia and contributes about 71% of the world total tilapia production. In Nigeria, Tilapia culture is a promising aquaculture business. In this study, we estimated the economic profitability of small-scale production of O. niloticus in semi flow-through system at three stocking density using the profitability index and the viability index. The economic profit indices measured were Gross profit, profit index and incidence of cost while the viability index was benefit/cost ratio. These were computed from the record kept during the experiment, which included stocking densities, type of feed used, labour cost, and other input cost. The results of the experiment suggested that fish fed Multi-feed were more profitable than those feed NIOMR feed. The results generated can guide farmers to develop standard farm enterprises and business plans.