Many general education teachers enter the field of education with limited knowledge of teaching students with special needs. However, the levels of teacher accountability and expectation of student academic achievement is required of both general education teachers and special education teachers who teach in inclusive classrooms. General education teachers continue to become fully licensed to teach with little or no coursework in special education, while being positioned in full inclusion classrooms. This qualitative case study was designed to investigate general education teachers' perceptions about inclusion. The conceptual framework for this study is supported by Bandura's research on self-efficacy within the social-cognitive theory. The participants in this study were 17 high school teachers in a metropolitan high school. This qualitative research included triangulated data from teacher interviews, artifacts, and classroom observations. Collected data were assessed and coded into themes and range of teacher perceptions and levels of competence. Results provided insights on the impact of professional development, teacher collaboration, teacher licensure programs, and student behavioral plans in regards to general education teachers in inclusive classrooms and their levels of self-efficacy. The findings of this study revealed that professional development and training for general education teachers on inclusion was underprovided but considered necessary. The findings in this study may assist in promoting positive social change through examining the potential for improved teacher professional development and teacher licensure programs by encouraging required coursework in special education for general education teachers, which will enable teachers to secure academic progress for all students while closing the gaps in education.