Each maceration with the 3 first solvents lasted 48 h under excitement, residual marc being kept to be extracted with the following solvent. After filtration and concentration, three dry extracts were obtained: CSE1 (petroleum ether), CSE2 (chloroform), CSE3(ethanol). The marc resulting from the maceration with ethanol was extracted for 10 min in boiling water. The water extract was left to cool for 4 h then filtrated before being centrifuged (30 min,7000 G) and finally freeze-dried to afford dry extract CSE4 (water).CSE1 and CSE2 were solubilized inDMSOwhile CSE3 and CSE4 were
solubilized in distilled water before being fed to the rats.