Klotho can influence a number of intracellular signalling pathways such as the p53/p21, cyclic AMP and protein kinase C (PKC)
pathways [52].
In the kidney, Klotho facilitates the action of FGF23 by acting as a
coreceptor with the FGF receptor [62].
It acts as a glycosidase to regulate the activity of ion channels
such as the TRPV5 channel (Fig. 2) [63,64] and the renal outer
medullary potassium channel 1 (ROMK1) [65].