Apparent homogeneity or heterogeneity among gender should not be overinterpreted. The primary efficacy endpoint and the reference group for each cardiovascular disease (CVD) area/drug are as follows. Acute coronary syndrome (ACS): cangrelor: the composite of all-cause mortality, myocardial infarction (M), ischemia-driven revascularization, or stent thrombosis; prasugrel and ticagrelor: the composite of CV death, MI, or stroke (clopidogrel as the reference group for all 3 drugs).