5.3: TIMING THE INITIATION OF RRT
5.3.1: We suggest that dialysis be initiated when one or more of the following are present: symptoms or signs attributable to kidney failure (serositis, acid-base or electrolyte abnormalities, pruritus); inability to control volume status or blood pressure; a progressive deterioration in nutritional status refractory to dietary intervention; or cognitive impairment. This often but not invariably occurs in the GFR range between 5 and 10 ml/min/1.73 m2. (2B)
5.3.2: Living donor preemptive renal transplantation in adults should be considered when the GFR is o20 ml/min/ 1.73 m2, and there is evidence of progressive and irreversible CKD over the preceding 6–12 months. (Not Graded)