Multiple strategies were used to educate and reduce family stress, explaining the high retention rate in spite of the high incidence of adverse events. These strategies also served to keep the patients and families engaged, involved, and motivated throughout the long treatment trial. It is felt that the high retention rate was due to the various traditional and creative methods employed by the study teams as well as the fact that the study coordinators were attentive, skilled in
knowledge area of CHC, ients. We believe that the patients in the study high drug compli- patients pediatiic nursing as well as in the and readily available for their pat efforts of the study coordinators to retain were also instrumental in achieving the ance rates previously noted; in the PEDS C study, reported taking 90% of the prescribed drug doses (Schwarz et al., 2011).