Fig. 7 In this figure, a plot of amino acid positions (x-axis) against
accessible surface area (ASA) ratio (y-axis) indicating the locations of
amino acids (exposed or buried) in the crystal structure of coleoid
serine protease is presented. Amino acids with an ASA ratio of more
than or equal to 50 % are considered to be exposed to the surrounding
solvent whilst those with a ratio lesser than 20 % are considered to be
buried. Three-dimensional structure of coleoid serine protease is also
presented and the episodically adaptive sites (HyPhy, MEME
approach) with buried and exposed side chains are indicated by
brown and blue labels, respectively. The sites which could not be
assigned to the aforementioned classes are indicated with white labels