Previous studies have documented the transient increase in cough reflex sensitivity during URI. Therefore, our subjects with URI were in a hypertussive state relative to their baseline. Because of the huge variation in cough sensitivity among the population, studies such as this one,
assessing the effect of a pharmacologic intervention on cough reflex sensitivity, must use each subject as his or her own control. Furthermore, the tremendous variation in baseline cough reflex sensitivity among individuals renders comparison of small groups irrelevant. In other words, subjects in our acute URI group are hypertussive relative to their own healthy baseline, not relative to the healthy volunteer group.
Previous studies have documented the transient increase in cough reflex sensitivity during URI. Therefore, our subjects with URI were in a hypertussive state relative to their baseline. Because of the huge variation in cough sensitivity among the population, studies such as this one,assessing the effect of a pharmacologic intervention on cough reflex sensitivity, must use each subject as his or her own control. Furthermore, the tremendous variation in baseline cough reflex sensitivity among individuals renders comparison of small groups irrelevant. In other words, subjects in our acute URI group are hypertussive relative to their own healthy baseline, not relative to the healthy volunteer group.
การแปล กรุณารอสักครู่..
