This study examined the effects of mindfulness-based stress reduction (MBSR) on the
brain–behavior mechanisms of self-referential processing in patients with social anxiety
disorder (SAD). Sixteen patients underwent functional magnetic resonance imaging while
encoding self-referential, valence, and orthographic features of social trait adjectives. Post-
MBSR, 14 patients completed neuroimaging. Compared to baseline, MBSR completers showed
(a) increased self-esteem and decreased anxiety, (b) increased positive and decreased negative
self-endorsement, (c) increased activity in a brain network related to attention regulation,
and (d) reduced activity in brain systems implicated in conceptual-linguistic self-view.
MBSR-related changes in maladaptive or distorted social self-view in adults diagnosed with
SAD may be related to modulation of conceptual self-processing and attention regulation.
Self-referential processing may serve as a functional biobehavioral target to measure the
effects of mindfulness training.
This study examined the effects of mindfulness-based stress reduction (MBSR) on the
brain–behavior mechanisms of self-referential processing in patients with social anxiety
disorder (SAD). Sixteen patients underwent functional magnetic resonance imaging while
encoding self-referential, valence, and orthographic features of social trait adjectives. Post-
MBSR, 14 patients completed neuroimaging. Compared to baseline, MBSR completers showed
(a) increased self-esteem and decreased anxiety, (b) increased positive and decreased negative
self-endorsement, (c) increased activity in a brain network related to attention regulation,
and (d) reduced activity in brain systems implicated in conceptual-linguistic self-view.
MBSR-related changes in maladaptive or distorted social self-view in adults diagnosed with
SAD may be related to modulation of conceptual self-processing and attention regulation.
Self-referential processing may serve as a functional biobehavioral target to measure the
effects of mindfulness training.
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