The experimental research described here was conducted to investigate the seismic behavior of reinforced precast concrete structures common in past and current Italian building practice and severely damaged by 2012 Emilia seismic sequences. Two 3:4 scaled two-bay, three-story precast concrete frames typical of the damaged buildings were tested under pseudostatic cyclic loading. The responses of the specimens with and without precast concrete panels were compared so as to quantify the interaction of the cladding panels with respect to the global response of the reference bare frame and with respect to the performance of the beam-column joints. The prevailing observations and conclusions, drawn from the experimental study, are summarized as follows: