Muscodor albus is an endophytic fungus of tropical tree species that produces volatile organic compounds (VOC’s) that have antibiotic
activity. A new isolate of this organism has been obtained from a small, unidentified vine, generally used by the indigenous people of the Tesso
Nilo region in Central Sumatra, Indonesia, to treat snakebites. This unique organism produces a number of VOC’s not previously observed in
other M. albus isolates including tetrohydofuran, 2-methyl furan; 2-butanone; aciphyllene, and large amounts of an unusual azulene
derivative. Noticeably absent from the VOC mixture was 1-butanol, 3-methyl-. Scanning electron micrographs of the organism showed a
unique fishnet-like deposit of what appears to be a biopolymer covering the hyphae. The ITS-5.8S rDNA partial sequence data showed 99%
identity to the original M. albus strain cz-620. In addition, an artificial mixture of some of the VOC’s produced by this new isolate generally
mimicked the inhibitory as well as lethal effects of the fungal VOC’s on the test microorganisms. One of the most sensitive test fungi was
Stachybotrys chartarum, an organism associated with the ‘‘toxic mold’’ syndrome of buildings. Fungi belonging to the Muscodor genus
regularly appear in tropical rainforests throughout the world and these isolates appear to have chemical, biological, and structural
characteristics that make them potentially useful in medicine, agricultural and industrial applications.
# 2005 Elsevier Ireland Ltd. All rights reserved.
Keywords: Endophyte; Volatile antibiotics; Rainforest fungi; Scanning electron microscopy; Mass spectrometry; Ribosomal DNA
1. Introduction
Muscodor is a fungal genus that, so far has only been
isolated as
Muscodor albus is an endophytic fungus of tropical tree species that produces volatile organic compounds (VOC’s) that have antibioticactivity. A new isolate of this organism has been obtained from a small, unidentified vine, generally used by the indigenous people of the TessoNilo region in Central Sumatra, Indonesia, to treat snakebites. This unique organism produces a number of VOC’s not previously observed inother M. albus isolates including tetrohydofuran, 2-methyl furan; 2-butanone; aciphyllene, and large amounts of an unusual azulenederivative. Noticeably absent from the VOC mixture was 1-butanol, 3-methyl-. Scanning electron micrographs of the organism showed aunique fishnet-like deposit of what appears to be a biopolymer covering the hyphae. The ITS-5.8S rDNA partial sequence data showed 99%identity to the original M. albus strain cz-620. In addition, an artificial mixture of some of the VOC’s produced by this new isolate generallymimicked the inhibitory as well as lethal effects of the fungal VOC’s on the test microorganisms. One of the most sensitive test fungi wasStachybotrys chartarum, an organism associated with the ‘‘toxic mold’’ syndrome of buildings. Fungi belonging to the Muscodor genusregularly appear in tropical rainforests throughout the world and these isolates appear to have chemical, biological, and structuralcharacteristics that make them potentially useful in medicine, agricultural and industrial applications.# 2005 Elsevier Ireland Ltd. All rights reserved.Keywords: Endophyte; Volatile antibiotics; Rainforest fungi; Scanning electron microscopy; Mass spectrometry; Ribosomal DNA1. IntroductionMuscodor is a fungal genus that, so far has only beenisolated as
การแปล กรุณารอสักครู่..
