Anticancer Activity
Animal studies have set the stage for further
investigation into the chemoprotective activity of d-limonene
for several types of cancer. Several experiments
demonstrated inhibition of chemically-induced mammary
cancer in rodents administered either orange peel
oil or pure d-limonene.21-24 Inhibition occurs in either
the initiation or promotion phases, depending on the
chemically-induced medium used.25-27 Other animal
trials demonstrated d-limonene inhibited development
of liver cancer, pulmonary adenoma, and forestomach
tumors