The mainvolatileoilsofblackseed(thymoquinon,
dithymoquinone,thymohydroquinoneandthymol)have
been reportedtoreducethe3-hydroxy-3-methyl-glutaryl-
CoA reductase(keyenzymeincholesterolsynthesisreg-
ulation) intheliver(El-Dakhakhnyetal.,2000). Thelower
of de novo cholesterolsynthesishasbeenreportedto
increasetheexpressionoflow-densitylipoproteinrecep-
tors onhepatocytes,resultinginhigherLDLuptakebythe
liverhepatocytesandultimatelylowerbloodLDL-Ccon-
centration