Results Compared with placebo, blood pressure lowering regimens
reduced the risk of major cardiovascular events by about a sixth per 5
mm Hg reduction in systolic blood pressure in individuals with (hazard
ratio 0.83, 95% confidence interval 0.76 to 0.90) and without reduced
eGFR (0.83, 0.79 to 0.88), with no evidence for any difference in effect
(P=1.00 for homogeneity). The results were similar irrespective of
whether blood pressure was reduced by regimens based on angiotensin
converting enzyme inhibitors, calcium antagonists, or diuretics/β blockers.
There was no evidence that the effects of different drug classes on major
cardiovascular events varied between patients with different eGFR (all
P>0.60 for homogeneity).