Meanwhile, HA-producing recombinant Lactococcus lactis
LL-NAB was constructed by coexpressing hasA and hasB
gene of Strep. equisimilis subsp. zooepidemicus in a nisincontrolled expression system (Chien and Lee 2007).
Recently, Streptococcus thermophillus YIT2084 strains have
been transformed to produce more than 1 g l1 HA by
overexpressing endogenous hasA, hasB and glmU derived
from nonpathogenic bacteria (Izawa et al. 2011). In our
recent study, we have demonstrated that certain strains of
lactobacilli such as Lactobacillus rhamnosus FTDC 8313
and Lactobacillus gasseri FTDC 8131 were also capable of
producing HA at concentrations exceeding 1 g l1 when
cultivated in skimmed milk, thus suggesting its dermatological potentials