the daily self-reported data were used for all analyses.For each patient,for each day,taking a drug was defined as taking at least a fraction of a pill per day,regardless of dose.Taking a medication class was defined as taking any drug within the medication class per day.A patient was considered to have a stable drug combination when the same combination of one or more drug was taken for 50% of days.The stable drug combinations were determined to focus the analysis on medications used long-term.For all patients,the number of daily changes to the drug combination was also calculate