Over the years, OPs have been shown to affect hundreds of enzymes, as well as receptors and signal transduction systems. Thus, a first important issue is to compare the relative potency of OPs toward these targets and toward AChE. It is also important to determine whether the observed effect or interaction also occur with the parent compound, whose concentrations in the body may be higher than that of the oxon. Verification of the findings in vivo would also be relevant.