Second Level Imaging AnalysisIn the group analysis, the contrast (con*.img) images from the individual analyses of each individual participant were combined in a second level, random-effects model. To test for differences in patterns of functional connectivity between the healthy and stroke groups, between-group differences were evalu- ated using two-sample t tests. To test for differences in patterns of functional connectivity within the stroke group between the 1-month and 6-month time points, within-group differences were evaluated using paired t tests. In order to identify how differences in functional connectivity over time might be associated with changes on clinical test scores, individual changes in TDT scores over time were included as a regressor in subsequent correlation analyses in the group-level random-effects analysis of change in functional connectivity for the stroke group. Only clusters with p-values <0.05 (false discovery rate, FDR, corrected) are reported as significant. Anatomical localization of significant clusters was defined using the anatomy toolbox in SPM8, which is based on probabilistic cytoarchitectonic maps (60).
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