The high motor-vehicle crash rate of young drivers may be attributed to both driving inexperience and a greater tendency to engage in risk-taking behavior. This study examines risk-taking behavior, as indicated by single-vehicle crashes and injury crashes, and factors associated with these behaviors, based on measures of demographic, psychosocial, and substance use obtained from high school senior questionnaires. Because previous work indicated different predictors for young men and young women, separate logistic regression analyses were conducted. For young women, propensity toward cigarette use was associated with higher rates of single-vehicle crashes; while race, alcohol misuse, and friends' involvement with alcohol and marijuana were associated with injury crashes. For young men, availability of substances, driving frequency, alcohol misuse, and propensity toward marijuana use were associated with higher rates of single-vehicle crashes. Young men's living situation, availability of substances, and marijuana use were related to injury crashes.