TLRs participate in the activation of the phagocytes as a result of encounter with microbes.
-These various receptors promote the phagocytosis of the microbes and stimulate the microbicidal activities of the phagocytes.
-Activated phagocytes secrete cytokines, which induce leukocyte infiltration into sites of infection (inflammation).
-Injury to normal tissue is a pathologic effect of inflammation.