Severe
Signs and symptoms are often life-threatening and can result in permanent morbidity or death if not managed appropriately.
Cardiopulmonary arrest is a nonspecific end-stage result that can be caused by a variety of the following severe reactions, both
allergic-like and physiologic. If it is unclear what etiology caused the cardiopulmonary arrest, it may be judicious to assume
that the reaction is/was an allergic-like one.
Pulmonary edema is a rare severe reaction that can occur in patients with tenuous cardiac reserve (cardiogenic pulmonary
edema) or in patients with normal cardiac function (noncardiogenic pulmonary edema). Noncardiogenic pulmonary edema
can be allergic-like or physiologic; if the etiology is unclear, it may be judicious to assume that the reaction is/was an allergiclike
one.
Severe reactions include