Lycopene and beta-carotene have been proposed to negatively affect cancer cells or the development of cancer by modulating cell-cycle progression and cell proliferation. The de-regulated cell cycle is one of the hallmarks of cancer cells. These cells have disturbed cell cycle and inability to control their rate of proliferation. A rate-limiting step in the cell cycle that is often disturbed in cancer is the progression of cells through the first gap (G1) phase (22). Recently, several reports have shown that lycopene can induce cellcycle arrest at the G1phase in human hepatocarcinoma cells, and G0/G1arrest and S phase block in human prostate cancer cell lines LNCAP and PC3.