The ethanolic fruit extract of Psidium guajava possesses anti-diarrheal activity and this justifies the use of this plant as herbal remedy against diarrhea. The plant can be considered to be safe for use as an anti-diarrhea remedy given the high LD50 of 10715mg/Kg that was determined in this study. The plant contains high levels of phytochemicals especially tannins and flavonoids which could be responsible for its anti-diarrheal activity. Studies need to be done on different fractions of the extract and other part of the plants since in this study only fruits were used. Chromatographic techniques need to be used to obtain pure fractions, as this may lead to an increase in efficacy. Chronic toxicity effect of Psidium guajava needs to be done if it is to be used in management of diarrhea.