Concomitant use of dexamethasone further reduces postoperative pain and PONV after TKA without increased risks for wound complications in patients managed using a multimodal pain and PONV regimen. We propose incorporating concomitant use of single, low-dose dexamethasone in a current multimodal regime after TKA because it is a simple, effective, and inexpensive intervention that is not associated with any apparent increased risk of infection or wound complications, although this last issue should be confirmed in larger multicenter trials or meta-analyses of randomized trials.