Thus, the primary objective of this article is to present a structured review of the scientific ASRH research literature in the English-speaking Caribbean from 1998 when the Caribbean Youth Health Survey was completed through 2009. Specifically, we use a multidimensional theoretical framework to guide the search for studies and to systematically identify the risk and protective factors that influence ASRH in the Caribbean. The second objective is to identify the major gaps in the literature and articulate directions for future research.