Based on our previous reports and those of other groups,6, 7, 8 the symptoms of advanced cancer patients are multiple, concurrent, and tend to be moderate or severe in intensity. These studies used to focus on individual symptoms in various patients with malignancy.9 Individual, symptom-oriented therapeutic strategies raise some important concerns, such as polypharmacy and drug side effects,10 and the tendency to emphasize management of a single symptom at the expense of others may compromise quality of life.9, 11