This preliminary study focuses on the effects of lime juice (Citrus aurantifolia) on some clinical and laboratory characteristics of children with SCA. Children with SCA who were given lime juice for 6 months experienced fewer significant painful episodes than the controls. This finding gave credence to findings that lime juice is a good food supplement for people with SCA because of its high content of vitamin C and amino acids, particularly phenylalanine.8–10 It is also very rich in flavonoid compounds such as rutin and hesperidin, a glycoside of flavonone.10 Vitamin C is a potent antioxidant with proven antisickling properties.4 Phenylalanine has also been demonstrated to inhibit polymerization of deoxygenated hemoglobin S by about 95.9% in one in vitro study.10 The metabolites of flavonoid compounds are known to improve capillary blood flow and exert profound stabilizing effects on the membranes of the red blood cells, consequently reducing risk of sickling.1