This research was conducted to determine the toxicity of ethanol extracts from Bosenbergia rotunda on
male rats. Extracts at doses of 60, 120 and 240 mg/KgBW/day were orally administered to 27 male rats for 60
days, while a control group received distilled water. The body weight, hematological and blood biochemical
values as well as histopathologic architecture of the kidney and liver were examined. The results showed that
the extracts had no effect on the body weight, regardless of the dosage used. All hematological parameters,
including the total white blood cell count, the differential white blood cell count, packed red cell volume (PCV)
and hemoglobin were the same as those of the control. The kidney and liver functions, including blood urea
nitrogen (BUN), creatinine (Crea), aspatate aminotransferase (AST) and alanine aminotransferase (ALT), were
within the normal range. No histopathologic changes of liver or kidney were observed. It can be concluded that
ethanol extracts of B. rotunda at all doses used in the present study have no toxic effect on male rats.
This research was conducted to determine the toxicity of ethanol extracts from Bosenbergia rotunda onmale rats. Extracts at doses of 60, 120 and 240 mg/KgBW/day were orally administered to 27 male rats for 60days, while a control group received distilled water. The body weight, hematological and blood biochemicalvalues as well as histopathologic architecture of the kidney and liver were examined. The results showed thatthe extracts had no effect on the body weight, regardless of the dosage used. All hematological parameters,including the total white blood cell count, the differential white blood cell count, packed red cell volume (PCV)and hemoglobin were the same as those of the control. The kidney and liver functions, including blood ureanitrogen (BUN), creatinine (Crea), aspatate aminotransferase (AST) and alanine aminotransferase (ALT), werewithin the normal range. No histopathologic changes of liver or kidney were observed. It can be concluded thatethanol extracts of B. rotunda at all doses used in the present study have no toxic effect on male rats.
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