The conventional view of LOH in cancer has been as
a mechanism of inactivation of tumour suppressor
genes. This view does not completely explain preferential
loss of the Pro allele at position 1170 of the HER2
oncogene among HER2-negative cancers. Other known
or putative tumour suppressor genes targeted by genetic
rearrangements of 17q play a causative role in the
development of HER2-negative tumours [