C production from hemato- poietic stem cells has been a focus in regenerative medi- cine.6-8 Undifferentiated stem cells confer the advantage of lifelong production in bone marrow. Given the right condi- tions, these stem cells have the potential to differentiate into mature RBCs after undergoing multiple steps in matura- tion. Despite the novelty of this recent tactic, many studies have been optimistic toward this end, and clinical therapeu- tic use may be possible sooner than previously predicted. If successful, this may be a solution to the worldwide short- age of blood supply. Our paper aims to discuss the pros- pects of the production of RBCs from stem cells based on our research experience.9-12